UROSCOUT-1 is an international study investigating the accuracy of the UroScout urine test in detecting bladder cancer and upper urinary tract cancer. The aim of the UROSCOUT-1 study is to determine if the developed urine test is accurate enough to rule out the possibility of bladder cancer and avoid unnecessary bladder cystoscopies. Hospitals from Finland, Canada, and Japan are participating in the study.
The UROSCOUT-1 study is registered on ClinicalTrials.gov (identifier NCT06310759).
Patients participating in the study collect 100 milliliters of urine and mail it to a laboratory that performs the UroScout test. The urine test result is compared with the result obtained from bladder cystoscopy.
Frequently Asked Questions
I collected a urine sample in the bag, but the bag does not fit in the box?
Verify that the bag contains no more than 100 mL of urine, and squeeze out excess air from the bag before sealing it.
Can I collect a urine sample if I have already undergone a bladder cystoscopy or ureteroscopy?
Yes, we do accept urine samples collected after cystoscopy or ureteroscopy. Such samples provide us with additional information about the impact of these operations on the representativeness of urine samples.
There is visible blood in my urine, can I still provide a sample?
Yes, you can provide a sample; we accept all urine samples regardless of symptoms.
Are there any risks associated with participating in the study?
The UROSCOUT study is completely safe, as it is an observational study and therefore does not affect your treatment. Bladder cystoscopy and all subsequent treatments are carried out according to normal treatment practice. If you participate in the study, we only ask you to collect one urine sample by urinating into a bag or cup. The urine collection kit will be mailed to your home.
How does the UroScout urine test detect cancer?
The test analyzes cells in the urine sample, looking for DNA mutations indicative of bladder cancer and upper urinary tract cancer.
Publications
Sensitive Detection of Urothelial Cancer via High-volume Urine DNA Analysis
European Urology (2025)
Jussi Nikkola, Lauri Ryyppö, Juuso Vuorinen, Heini Kallio, Hanna Selin, Pyry Jämsä, Jonne Åkerla, Tuomo Virtanen, Tarmo Pekkarinen, Antti Kaipia, Johanna Pulkkinen, Gillian Vandekerkhove, David C. Müller, Alexander W. Wyatt, Peter C. Black, Matti Nykter, Thea Veitonmäki, Matti Annala